药对丹参-当归作用阿尔茨海默病的网络药理学机制研究

A study on the network pharmacological mechanism of salvia miltiorrhiza-angelica

摘要:

为了研究药对丹参-当归作用于阿尔茨海默病的可能机制，通过中药系统药理学分析平台（TCMSP）筛选出丹参、当归的活性成分，寻找其相关的潜在靶点；并通过预测平台人工检索候选化合物的潜在靶点是否与阿尔茨海默病相关；将靶点信息通过DAVID数据库、KEGG数据库进行靶点和通路分析；构建化合物-靶点作用网络，靶点-通路网络图，化合物-靶点-通路图. 结果表明：药对丹参-当归中具有潜在作用阿尔茨海默病活性的成分有β-谷甾醇，豆甾醇，丹参酮Ⅱ、丹参新酮、隐丹参酮、二氢丹参酮，其可能通过抗炎、抗氧化、免疫系统、细胞周期、钙信号通路、神经受体-配体相互作用等机制对阿尔茨海默病起作用.

Abstract:

This study aimed to study the mechanism of the effect of Salvia miltiorrhizae-Angelica. The active ingredients of Salvia and Angelica and potential targets of candidate compounds were screened in TCMSP. And artificially retrieval of potential targets of candidate compounds through prediction platforms related to Alzheimer's disease. Target information was imported into the DAVID database and KEGG database for target and pathway analysis to construct the compound-target action network, target-pathway network graph, and compound-target-pathway graph. The results indicate that the active ingredients for Alzheimer's disease in Salvia and Angelica were β-sitosterol, stigmasterol, tanshinone Ⅱ, tanshinone, cryptotanshinone and dihydrotanshinone, which may play a role in Alzheimer's disease through mechanisms such as anti-inflammatory, anti-oxidant, immune system, cell cycle, calcium signaling pathway and neural receptor-ligand interaction.