吲哚-2,3-环氧的酸开环反应

The ring opening reaction of indole-2,3-epoxides with acid

摘要:

以吲哚-2,3-环氧化合物和商品化的酸为主要反应物, 经环氧的酸开环反应, 可以高收率的得到一系列的酯基取代的二氢吲哚化合物. 该方法简便高效, 首次实现了吲哚-2,3-环氧化合物在酸性条件下的开环反应, 为酯基取代的吲哚化合物的合成提供了一条新的合成方法.

Abstract:

A series of dihydroindoles 3-ester substituted compounds can be obtained in high yield by the acid ring-opening reaction of epoxy using indole-2,3-epoxy compounds and commercial acids as the main reactants. This method is simple and efficient, and it is the first time to realize the ring opening reaction of indole-2,3-epoxy compounds under acidic conditions, which provides a new synthesis method for the synthesis of ester substituted indole compounds.