Combined utilization of metformin and Salvia miltiorrhiza bge. f. alba on diabetes mellitus

Abstract:

In order to observe the combined utilization effect of metformin and Salvia miltiorrhiza bge. f. alba on diabetes mellitus type 2, MTT method, glycemic and insulintest, hematoxylin eosin (HE) staining and immunohistochemical staining were carried out in this paper. MTT test results show that combined utilization of metformin and Salvia miltiorrhiza bge. f. albacan inhibit the apoptosis of INS-1 cells. In the treatment of diabetic rats, combined utilization appears to effectively control to blood sugar. HE staining and immunohistochemical staining results show that Salvia miltiorrhiza bge.f. alba can promote the production of Bcl-2 proteins, weaken the ability of Bax proteins to induce apoptosis, in the mean time, metformin has the effect on increasing blood sugar uptake and utilization, ultimately achieve glycemic control purposes. Combined utilization of metformin and Salvia miltiorrhiza bge. f. alba has the potential to be an effective method to the treatment of diabetes.