Abstract:A class of nonautonomous second order Hamiltonian systems with mixed condition are considered in this paper.The existence of periodic solution is obtained using Saddle Point Theorem.Our result extends some previously known results.

Abstract:In this paper,we investigate the existence of positive solutions for the following fourth-order Sturm-Liouville boundary value problem with $p$-Laplacian $$(\phi_{p}(u''(t)))''+q(t)f(t,u(t),u''(t))=0,\quad t\in (0,1),$$ $$\alpha u(0)-\beta u'(0)=0,\gamma u(1)+\delta u'(1)=0,u''(0)=0,u'''(0)=0,$$ where~$\phi_{p}(s)=|s|^{p-2}s,~p>1;f:[0,1]\times[0,+\infty)\times R\rightarrow[0,+\infty)$~is continuous;~$q(t)\geq0,t\in(0,1).$

Abstract:In this paper, we determine the forbidden set, introduce an explicit formula for the solutions, and discuss the global behavior of a rational difference equation x_(n+1)=(x_n x_(n-k))/(αx_n+βx_(n-(k+1)) ), where inter k∈N, inter n∈N∪{0},α,β are real numbers, the initial conditions (x_(-(k+1) ),x_(-k),⋯,x_0 )∈R^(k+2).

Abstract:Using Young’s functions, we define the Bloch-Orlicz space and show that the Bloch-Orlicz space is isometrically equal to a special certain -Bloch space. By the analysis methods and constructing test functions, we investigate the boundedness, compactness and boundedness from below of the composition operator on Bloch-Orlicz type spaces of the unit ball, and obtain the sufficient and necessary conditions of boundedness、compactness and boundedness from below of the composition operator.

Abstract:The Kahler angle of a surface immersed in an almost Hermitian manifold is an important invariant which can be used to measure the deviation of the surface from being a complex (or pseudo-holomorphic) one and, in particular, the surface with a constant Kahler angle has been an interesting object in the study of submanifolds for years. In this paper, we shall prove two rigidity theorems for complete self-shrinkers of mean curvature ow with constant Kahler angle, which are immersed in the complex Euclidean space C3 of dimension 3. These are direct extensions of some known theorems for self-shrinkers immersed in C2.

Abstract:We studied the existence of positive solutions for nonlinear Caputo fractional differential equations with integral boundary value conditions. The existence results of positive solutions for the boundary value problems are obtained by applying the properties of Green function and Schauder fixed point theorem，which partly extend the corresponding results of fractional differential equations. Two examples are also presented to illustrate the applications of our main results.

Abstract:Itis well known that in quantum information quantum relative is monotonically decreasing under the completely positive and trace-preserving maps. For a new proposed sandwiched R\'enyi quantum relative, a map that is linear trace-preserving and whose Hilber-Schmidt adjoint map satisfies Schwarz inequality, monotonicity still holds. We give a new proof of monotonicity of sandwiched R\'enyi relative entropy for $\alpha\in[\frac{1}{2},1)$. The proof is based on complex interplotation techniques, which already has been used to prove monotonicity under trace-preserving and positive map for $\alpha\in(1,\infty)$.

Abstract:By using the Lyapunov-Schmidt procedure and the connectivity theory of the solution set of compact vector fields,~we develope the method of upper and lower solutions and obtain the existence of solutions for a third-order periodic boundary value problem at resonance~ $$ \left\{\begin{array}{ll} v'''(t)=f(t,v(t)),~~\ \ \ t\in [0,T],\\[2ex] v^{(i)}(0)-v^{(i)}(T)=0 ,\ \ \ i=0,1,2, \end{array} \right.\eqno $$ where~$f: [0,T]\times \mathbb{R}\rightarrow \mathbb{R}$~is continuous and bounded.

Abstract:Maneuvering target tracking is an important part of radar application system, target tracking accuracy is regarded as an important index when evaluating an algorithm's performance for the maneuvering target tracking,it is the focus of attention of most people. The characteristics were summarized through the analysis and comparison of four traditional Alpha-Beta filtering algorithms, and according to these characteristics, an Adaptive alpha-beta filter algorithm was obtained by improving traditional algorithms. Compared with the traditional Alpha-Beta filtering algorithm, the Adaptive Alpha-Beta filter algorithm is best in overall filtering results, and also has the highest accuracy.

Abstract:The reliability of data transmission has become a hot issue of car networking. The reliability method of data transmission between cars is proposed in this paper, and it is solved with wavelet transform and multi-mosquito algorithm. At the same time, the search direction is introduced by the allocation mechanism and decision-making power to guide, which is in order to accelerate the convergence speed of this algorithm. Finally, the simulation experiments are conducted to study the key influence factors, and the relationships between packet size, vehicle spacing, transmit power, vehicle speed and data success rate. Compared to other algorithm, the result shows that this algorithm has better adaptability.

Abstract:In this paper, the region labeling method is proposed for the shortcomings of single point labeling method in traditional stock forecasting. The region labeling method can provide more useful information for training classifier and alleviate the problem of class imbalance to a certain extent, which is also more suitable for practical needs. At the same time, this paper constructs an RCS-Trader model, which uses cost-sensitive support vector machines and F_S measure to optimize. Compared with traditional stock predicting methods, RCS-Trader model works better and has higher return rate of investment.

Abstract:Code packing brings a new conception to protect software, but it also serves as an umbrella for malicious code. It has been intensified that malware using packing techniques to evade detection and it troubles analysts due to the massive variants of malware produced by code packing. Traditional unpacking methods based on feature matching gradually become inapplicable because they can’t cope with the change of shell version and type, so a general unpacking method would be very useful. In this paper, we proposed a common unpacking method based on dynamic binary analysis platform, according to the property that packer will restore the original code during the process of executing. The experimental results show that our method can effectively locate the original entry point of the program, extract the code that has been hidden, and can get the accurate image size of the process in the memory, which can effectively realize dynamic unpacking of the shell code.

Abstract:License plate detection is an important part of the license plate recognition system, which deeply affects the accuracy of license plate recognition. A method for cascade adaboost license plate detection based on HSV color model and multi-block local binary patterns (MB_LBP) is presented to realize fast and accurate license plate detection and recognition. Firstly, the license plate image is transformed from RGB color space to HSV color space, and the ratio of the blue pixels to the total pixels of the license plate is counted to construct the first class strong classifier. Then, the MB_LBP feature is extracted from the license plate character samples, and the feature selection and the classifier training are carried out by using the Adaboost classifier training method. Finally, a new license plate detection algorithm is formed by using the Cascade structure detection method. Experiments results show that the license plate detector improves the detection rate and the detection speed.

Abstract:In solving optimal problems, pigeon-inspired optimization algorithm (PIO) is easy to premature convergence and trap in local optimum, so this paper presents a cross pigeon-inspired optimization algorithm with cognitive factors. Firstly, map the compass operator and landmark operator no longer run independently, and them are mixed together and operated crosswise; Second, in the map and compass operator the cognitive factor of nonlinear increment was introduced, and regard as the inertia weight’s trigonometric functions; Finally, in the landmark operator, a compressive factor that was increasing gradually in the form of trigonometric functions was proposed to make path smoother. Simulation results showed that the improved algorithm search success rate had greatly improved, and not only effectively avoid premature convergence, but also jump out of local minima and had better optimization ability.

Abstract:F-frequency characteristics function is a new concept about lumped eigenvalue of the fractance approximation circuit. In order to quantitatively describe the approximation performance of F-frequency characteristics of the fractance approximation circuit, a series of concepts and corresponding mathematical functions about approximation performance analysis of F-frequency characteristics are proposed in this paper based on F-frequency characteristics function, including relative error, approximation accuracy, approximation bandwidth, approximation bandwidth exponent, K-diagram, F-index, approximation benefit, etc. And these concepts are used to analyze the Oldham fractal fractance approximation circuit to verify its effectiveness.

Abstract:Because of the complexity of the causes of earthquake prediction，it has been recognized an aporia by all over the world. In this paper, a new method based on Back-Propagation neural network (BP) and Self-Organizing Feature Map neural network (SOM) is proposed，and applied to the prediction of earthquake magnitude. Firstly, Clustering of the original seismic data by using Self-Organizing Feature Map neural network,, which has the inherent law of the samples together, after using BP neural network to the sample data for learning and prediction, the experimental results show that compared with linear regression prediction model and BP neural network prediction results, the increase of SOM clustering process can effectively reduce the prediction error. It shows that this method can effectively summarize the factors which are closely related to earthquakes and SOM is effective for the classification of the relevant magnitude parameters, and it can be as an effective assistant method to predict the magnitude by using the fuzzy prediction method.

Abstract:In order to improve the medical image sharpness and contrast, and improve the computational efficiency, we proposed the gray level DAG maximum entropy based on quantization resolution for Medical image tone enhancement. Firstly, we used a simple piecewise autoregressive (Piecewise autoregressive PAR) image target model for recovery, and taked into account the error of analog to digital conversion to use least squares algorithm to estimate PAR model parameter, which obtain high resolution image histogram restoration model; Secondly, aiming at the problem of low contrast may exist, the least squares algorithm for constrained optimization problems was modeled in DAG, which constructed a hue preserving constraint optimization model of maximum entropy image enhancement, and the characteristics of the DAG figure Monge theorem was used to reduce the computational complexity; Through the above two steps, the image details and contrast enhancement in the process of medical image enhancement are realized. The simulation results show that the proposed algorithm can provide more effective medical image enhancement effect.

Abstract:Magnetoreceptor existing in the living beings is the mechanism supporting the biological magnetic navigation, and the process of magnetic information transforming to neural signals is the key process of magnetoreceptor mechanism, however it is still hypothesis. In this paper, the process of magnetic information transforming to nerve signals of the mechanism of electromagnetic induction, magnetic protein biocompass and magnetite-based magnetoreceptor are characterized, and then a possible way to cognize the process of magnetic information transforming to nerve signals from the point of view of theory is presented .

Abstract:We present virtual time evolution-split operator method for solving the two-dimensional time- dependent Schrodinger equation. In this method, the Hamiltonian is accessed by employing the two representations of the wave function. One is a coordinate representations, in which the coordinate dependence of the wave function is discretized using a discrete variable constructed from the Coulomb wave function. Another is the momentum representation, the time function is expanded in the corresponding. As an example, the present method is applied to the harmonic oscillator. It is found that there exists coulomb interaction when two electrons are stored in the harmonic oscillator potential well. We explore the qualitative change of two electrons ground state wave function by altering the strength of the harmonic oscillator potential. When harmonic oscillator potential is weak, the wave functions are not overlapped, which can be used an evidence for presentence of Wingner lattice. With the increase of harmonic oscillator potential, the wave functions begin to overlap, which is similar to the mokecules formation.

Abstract:Abstract: The model of porous particles was built in this paper, and the optical properties of them were carried out utilizing discrete dipole approximation and Bruggeman effective medium theory for the number of air pockets from 49 to 299. After analyzing and comparing the scattering properties of porous particles obtained by two computing methods, we found that the effective medium theory has a good validity for the extinction efficiency, the absorption efficiency and the scattering efficiency when the number of air pockets less than a certain value, but not vice versa. While for the single-scattering albedo and the asymmetric factor, the effective medium theory always keeps a good validity in the research scope of this paper. The results also revealed that the inference of the doctor Michael about the validity of effective medium theory in light scattering of porous particles was not comprehensive.

Abstract:A magnetoresistance (MR) device was proposed by depositing two parallel ferromagnetic stripes on top and bottom of a semiconductor heterostructure. In order to manipulate its performance, we dope a tunable δ-potential into the device by atomic layer doping technique. Transmission, conductance and MR ratio are calculated for the δ-doped MR device. It is confirmed that an obvious MR effect still exists in the device even though a δ-doping is comprised. Results show that the MR ratio varies intensely with the weight and/or the position of the δ-doping. Therefore, one can manip- ulate structurally the MR device by altering the δ-doping, and a tunable MR device can be obtained for magnetic information storage.

Abstract:The lattice thermal conductivity of lithium fluoride (LiF) is accurately computed from a first-principles theoretical approach based on an iterative solution of the Boltzmann transport equation. Real-space finite-difference supercell approach is employed to generate the second- and third-order interatomic force constants. Then the related physical quantities of LiF crystal are calculated by the second- and third- order potential interactions at 30 K to 1000 K. The calculated lattice thermal conductivity 13.89 W/(m∙K) for LiF at room temperature agrees well with the experimental value, demonstrating that the parameter-free approach can furnish precise descriptions of the lattice thermal conductivity of this material.

Abstract:In the present paper, we propose an effective method to enhance the intensity of the harmonic spectrum by using the He+ ion chain model. Through solving the time-dependent Schrödinger equation, the harmonic spectra from the single He+ ion and the He+ ion chain have been theoretically calculated. Moreover, the ionization probabilities, the time-frequency analyses of the harmonic spectra and the time dependent wave functions have been used to explain the harmonic emission process and the electron motion. Results show that the harmonic intensity can be remarkably enhanced and the harmonic cutoff can be extended.

Abstract:We investigate theoretically the nonclassical properties, such as cross correlation function and sub- Poisson distribution effect, for the nonlocal coherent photon-added two-mode circular state. The results show the superposition number and excitation number have significant effect on these properties. When the superposition number , the value of cross correlation function decreases monotonously with the increasing of the average photon number of single-mode and the nonlocal coherent photon-added two-mode circular state has the cross correlation effect. Increasing the superposition number , the cross correlation effect will be reduced. When the superposition number , sub-Poissonian distribution effect of the nonlocal coherent two-mode photon-added circular state can be observed only when single-mode average photon number is greater than a certain threshold value.

Abstract:The Tb3+-TiO2 photocatalyst with different amounts of doped Tb3+ and under different calcination temperatures were synthesized by sol–gel method, and characterized by XRD and FT-IR and photocatalytic activity.Malachite green experiment was chosen to evaluate photocatalyst’s activity. The results showed that the obtained powder is anatase TiO2, and with the Tb3+ doped, which indicating that Tb3+ doped rare earth can refine the grain. The photocatalytic material experiments of malachite green degraded showed that, calcined at 400 ℃, Tb3+-TiO2 molar ratio of 2.5% catalyst, irradiated without lighting 3h, the degradation rate could be 81.1%. Key words：Sol-gel method; nano TiO2;Tb3+ doped TiO2; photocatalytic activity

Abstract:Porous ceramics with a high open porosity were prepared by employing low-cost kaolin, talcum powder, and alumina as major raw materials, cement as curing agent, and hydrophobic activated carbon powders as foam stabilizing agent via direct foaming. PdOOH catalyst was loaded on porous ceramics via immersion and reaction method. Methylene blue was used as the simulated pollutant in sewage, and also used as the degradable agent when sodium hypochlorite was decomposed by the palladium-based catalyst. Effects of the loaded amount of catalyst, temperature, and the amount of sodium hypochlorite on the degrading speed of methylene blue were investigated. The results indicate that the palladium catalyst loaded on porous ceramics can effectively catalyze the decomposition of sodium hypochlorite, and significantly improve the color fading speed of methylene blue by oxidation. The time required for color fading drastically decreases with the increment of temperature. It only needs 58 min for methylene blue (10mg/L, 50 mL) to fade to colorless when the temperature, the amounts of catalyst and sodium hypochlorite, and pH value are 40 oC, 0.4 g, 5 mL and 7.88, respectively.

Abstract:CaGd3F11:Eu3+ nanocrystals with the morphologies of nanoparticles were prepared by octylamine and oleic acid as capping ligands, and anhydrous calcium chloride, rare earth nitrate, n-octanol as the raw materials with solvothermal method. The products were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM) and fluorescence spectrophotometer. The results indicate that CaGd3F11 nanocrystals are well-crystallized and their sizes are uniform (about 5 nm). As a luminescence host, it shows higher emitting intensity with Eu3+ doping.

Abstract:The structure, phase transition and magnetism of Ni46Mn41In13-xSbx (x=0, 2, 4, 6, 8, 10, 12, 13) alloys have been systematically studied in this paper. The results demonstrate that the arc-melting samples display pure L21-type and atoms are arranged more orderly. Curie temperature and martensitic inverse transformation temperature reduce at x<6 and increase at x>6 gradually with increasing x. The magnetization-temperature curves indicate that substitution of In by Sb has a significant influence on the p-d hybridization interaction between p orbitals of main group element and d orbitals of transition metals, leading to a reverse trend of the magnetization of austenite and martensite with the increasing Sb content.

Abstract:Abscisic acid receptors play a pivotal role in regulation of environmental stress, its network is fundamental to elicit ABA pathway. In this research, Yeast two- hybrid system (Y2H), Pull down and Bimolecular fluorescence complementation (BiFC) assays were used to study the interaction between CARK4 and RCAR12. The result from Y2H showed an interaction of CARK4ΔN with RCAR12. The same from Pull down were confirmed in vitro. BiFC result indicated that CARK4 interacted with RCAR12 in Nicotiana benthamiana. Taken together, we can conclude that the interact on of CARK4 with RCAR12 is confirmed in vitro and vivo.

Abstract:Hydrogen sulfide (H2S) is the third endogenous signaling molecule after nitric oxide and carbon monoxide. Attention towards H2S has been increasing due to its significant role in the cardiovascular and nervous systems. Saccharomyces cerevisiae Sch9 is homologous to human S6K1, which regulate cell cycle as well as life span. The SCH9 deletion and limited increase in the intracellular H2S can prolong the lifespan of animals. They both are also involved in the mechanism of caloric restriction to extend life.In order to study whether SCH9 deletion can affect the metabolism of H2S in yeast . GYY4137 and NaHS were used as H2S donors and lead acetate paper was employed for testing H2S in SCH9 deletion strains RCD398, RCD399 and TS120-2d.Results indicated that synthesis of H2S is negatively regulated by SCH9 deletion strains with or without caloric restriction. Similarly, catabolism of H2S were down regulated.Thus we speculate that SCH9 deletion decreased synthesis and catabolism of H2S in yeast, which laid a theoretical foundation for further study of H2S metabolism.

Abstract:Abstract: The ecological environment protection of large-scale projects has been paid more and more attention to. However, engineering disturbance, lack of methodology and theory are the difficulties of making effective construction plans. In this research, we applied the distributed hydrological model (SWAT model) to explore the influence of Tianfu International airport construction to ecological hydrology of Juren River, which was partially occupied by the airport. The result showed that the R2 and NS were 0.81 and 0.71 in model calibration, 0.70 and 0.53 in model validation respectively, so the runoff simulation was reliable. Considering the airport construction and ecological compensation plans, two scenarios including "construction damage" and "downstream restoration" were set up. In "construction damage" scenario, the surface runoff increased by at least 10%, root infiltration increased by more than 20%, the actual evaporation value increased too, meanwhile the runoff and water production decreased, the results showed a significant construction damage effect. Surface runoff, water production and river runoff reduced significantly in "downstream restoration" scenario, so the ecological restoration is effective. This research provides a new idea and an objective basis for the construction plan of large-scale projects, which has certain instructive meaning to propose project ecological protection plans and ecological compensation strategies.

Abstract:Abstract：Objective:To solve these uncertain threat that carrier materials and a new drug which is synthesized by drug-drug conjugate through covalent bond bring, insteading by more easy drug delivery system through non-covalent bond. Methods: A novel composite drug nanoparticles (DOX-Cb nanoparticles) have been prepared by reprecipitation after hydrophobic anticancer drug Doxorubicin (DOX) and hydrophobic anticancer drug chlorambucil (Cb) being mixed. Then using 1H nuclear magnetism(1H NMR), DLS,SEM,AFM ,TEM, Hoechst staining,western and confocal experiment confirm that DOX-Cb nanoparticles,which have antitumor activity in vitro, are prepared. Results: 1H NMR confirms that DOX and Cb compound is formed via electrostatic force between amino group and carboxyl group. DLS,SEM,AFM and TEM confirm that Composite drug nanoparticles have regular morphology and a narrow size distribution. Cytotoxicity test by using three tumor models（MCF-7，A549，HepG2） shows Composite drug nanoparticles have better effect of killing tumor cells than free DOX and Cb. Hoechst staining and western’result suggest that Composite drug nanoparticles kill tumor by inducing tumor cells apoptosis. confocal experiment verifys DOX-Cb nanoparticles are easier endocytosed by tumor cells than DOX. Conclusion: A novel composite drug nanoparticles (DOX-Cb nanoparticles) have been prepared by reprecipitation through electrostatic force between DOX and Cb, and composite drug nanoparticles were prepared by this strategy having better antitumor effect.

Abstract:Mutations in the EGFR kinase are a cause of non-small-cell lung cancer. Deletions in exon 19 and the L858R (2573T>G) single point mutation constitute about 90% of all EGFR mutations. Selectively inactivate only mutant, not normal allele, could benefit patients with such mutations. Here, the editing efficacy and selectivity of CRISPR-Cpf1 and -Cas9 systems on EGFR L858R mutant allele were analyzed by dual-reporter assay in vitro. Near the mutation site, there are two TTTN protospacer adjacent motifs (PAMs) for Cpf1. 2573T>G substitution also leads to occurrence of a novel NGG PAM for Cas9. Thus we designed two AsCpf1 gRNA (gRNA1 and gRNA2) and one SpCas9 gRNA (gRNA3) and evaluated their potency and allele specificity in vitro using a dual fluorescent protein-based bioassay system. As a result, both AsCpf1 and SpCas9 demonstrated robust activities to induce specific editing of only 2573T>G mutant EGFR, not wild-type sequence. Our results support the potential applicability of both Cpf1 and Cas9 in precision medicine through highly specific disruption of mutant oncogenes.

Abstract:To explore the ability of cadmium resistance between the different rice genotypes and to find the effects on the rice germination when exposed to the different concentration of cadmium. Method: Eight kinds of rice were planted by using hydroponic and we conducted a comprehensive evaluation on the ability of resistance to cadmium stress between the different rice genotypes through the clustering analysis. Results: On account of the various genotypes and different physiological mechanism, there were a large difference on their cadmium resistance. The effect of mild cadmium stress on the seed germination of rice was more significant at the single inhibitory effect on rice seed vigor.With the increase of stress concentration, the effect of rice seed germination was greater.Sensitive varieties seems to be more brittle of rice root tip and bud color can not be timely turn to green phenomenon when under midle Cd stress. The comprehensive character of the index under mild heavy metal stress was more consistent with the correlation curve. Therefore, the selection of heavy metal resistant varieties under the condition of mild heavy metal stress was the most suitable to the actual situation.These eigth varieties of rice for experiment were divided into three types through the cluster analysis, which were tolerant respectively,sensitive and intermediate.The hybrid rice including G46-B,Ⅱ-32B,and R3203 were proved to be tolerant, which had the strongest ability of cadmium resistance.While the Wushansimiao, Guichao-2 and Guiyu-7 were the sensitive type and the cadmium resistance were the weakest.The results of this study provide valuable clues and materials for the breeding of heavy metal resistant varieties.

Abstract:Nephroblastoma, or named Wilms tumor, is the most common renal cancer in children. This study was aim to identify gene signatures and potential therapeutic target in nephroblastoma. Microarrays GSE11151 and GSE53224 were downloaded from GEO database. 53 Wilms tumor and five normal tissues profiles were screened by GO and KEGG enrichment analysis, and protein-protein interaction (PPI) network of the differentially expressed genes (DEGs) was constructed. In total, 404 DEGs were identified, including 385 up-regulated genes and 19 down-regulated genes. The biological processes of GO functional enrichment showed that up-regulated DEGs significantly involved in immune response, immune system process, and leukocyte cell-cell adhesion; while the down-regulated DEGS were related to excretion, metanephros development, and nephron development. In KEGG analysis, the DEGs were enriched in neuroactive ligand-receptor interaction, T cell receptor signaling pathway, and Chemokine signaling pathway. Five genes were identified as hub nodes from the PPI network, including PMCH, CCR5, CCR7, RGS1 and KNG1, which were mostly associated with Chemokine signaling pathway, G-protein coupled signaling pathway, and involved in shaping tumor microenvironment. In conclusion, the DEGs, particular hub genes, play significant roles in the development of nephroblastoma and might be the underlying target and diagnostic biomarkers for the treatment of nephroblastoma.

Abstract:TR1 is an E3 ligase localized in the plasma membrane, and the previous studies indicated that it played a key role in salt, drought and heat stress response in many plants.However, the molecular mechanism of its function is unclear, and the target protein interacting with it is not found.In this study, a yeast two-hybrid system screening using TR1-△119 as a bait was performed to screen the Normalized Universal Arabidopsis cDNA library and found 13 candidate proteins with potential interaction. Forward and reverse two-hybrid system multiple validation revealed that diploid yeast containing TR1 and CURT1C or TR1 and SWEET5 will grow on SD/-Trp/-Leu/-His and SD/-Trp/-Leu/-His/-Ade/X-α-gal minimal media and see blue colonies. BiFC technique also demonstrated that TR1 interacts with CURT1C and SWEET5,providing the foundation for further understanding of the functions and molecular reaction tolerance mechanism．