TAp73α-mediated cisplatin sensitivity was suppressed by miR-330 in colorectal cancer cell HCT116
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    Abstract:

    The p53 family member p73 is a transcription factor involved in the regulation of cell cycle, apoptosis and cancer cell drug-resistant. Here we reported that knockdown of p73 sensitized HCT116 colorectal cancer cells to cisplatin treatment independent of p53. Hsa-miR-330 (miR-330) was identified to be able to directly repress the expression of TAp73α. Overexpression of miR-330 decreased the protein levels of endogenous TAp73α and phenocopied the effect of p73 knockdown. Restoration of TAp73α eliminated miR-330-induced chemosensitivity toward cisplatin. Our results demonstrated a novel function of TAp73α to impair cisplatin sensitivity in colorectal cancer cells which can be repressed by miR-330, thus provided an effective strategy for therapeutic treatment of cisplatin-resistant cancer cells.

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Cite this article as: HUANG Ling, TONG Ying, XIAO Zhi-Xiong, ZHANG Yu-Jun. TAp73α-mediated cisplatin sensitivity was suppressed by miR-330 in colorectal cancer cell HCT116 [J]. J Sichuan Univ: Nat Sci Ed, 2016, 53: 228.

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History
  • Received:April 09,2015
  • Revised:May 06,2015
  • Adopted:May 13,2015
  • Online: May 30,2016
  • Published: