The expression and clinical significance of FEZF1 in colorectal cancer tissues and adjacent normal tissues

Abstract:

We explore the expression and clinical significance of FEZF1 protein in colorectal cancer tissues and adjacent tissues.In this paper, immunohistochemistry, Western Blot and cell experiments showed that FEZF1 was down-regulated in colorectal cancer tissues, and its expression was significantly correlated with tumor node metastasis (TNM) stage. When FEZF1 was low expressed, the proliferation and migration ability of RKO cells increased, and the proliferation ability of RKO cells decreased when FEZF1 was highly expressed. This study demonstrates that FEZF1 is a low-expression protein in colorectal cancer, its expression is associated with the occurrence and development of colorectal cancer, and FEZF1 inhibits the proliferation and migration of colorectal cancer cells.