Abstract:To improve the efficiency of cold chain logistics distribution and reduce logistics cost, a cold chain logistics distribution model is established to optimize both total distribution cost and customer satisfaction on the premise of comprehensively considering multiple distribution centers, customers dynamic demand and strategy of replenishment along the way. A principal objective method is used to deal with the inverse relationship between customer satisfaction and cost, and the dynamic problem is decomposed into a series of static scheduling sub-problems according to the time axis with five kinds of distribution cost considered. An adaptive large neighborhood search algorithm is designed to solve the peoposed model with three kinds of damage operators and three repair operators. Small, medium and largescale examples are calculated respectively, the results show that the algorithm performs well in terms of speed, accuracy and stability, and moreover, is adaptable and accurate in solving such problems. Compared with the dynamic distribution scheme without considering strategy of replenishment along the way, the cost is reduced by 23.06% and the customer satisfaction is improved by 8.69% by the strategy of replenishment along the way, this confirms the proposed distribution scheme can save distribution resources, reduce distribution cost and enhance the competitiveness of enterprises.